Bone Is Maintained Via A Delicate Balance Between Formation And Resorption, And Its Imbalance Leads To

phys.org

Research shows bone density is maintained by proteins that are also involved in hair color

Bone is maintained via a delicate balance between formation and resorption, and its imbalance leads to bone related diseases like osteoporos

Bone is maintained via a delicate balance between formation and resorption, and its imbalance leads to bone related diseases like osteoporosis, rheumatism and periodontitis. Researchers led by Osaka University have revealed that proteins named Rab32 and Rab38 play pivotal roles in bone resorption in osteoclasts. These proteins are also crucial for pigmentation of hair and skin. The researchers have published two articles, "Characterization of Rab32- and Rab38-positive lysosome-related organelles in osteoclasts and macrophages" in the Journal of Biological Chemistry and "Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts" in Cell Structure and Function.

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