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Artificial Kidneys For People With Kidney Failure May Be Closer Than We Think

Artificial kidneys for people with kidney failure may be closer than we think

Artificial Kidney Bioreactor Keeps Human Renal Cells Alive in Pigs
GEN - Genetic Engineering and Biotechnology News
Researchers say bioartificial kidney will make treatment for renal disease more effective and more tolerable.

More than 500k people in the US require dialysis every week due to kidney failure. Some of those people are able to receive organ transplants, but the waiting list is incredibly long and only about 20k people receive transplants every year. On top of that, a person's body can reject the transplanted organ, and even if it is successful the patient will have to take immunosuppressant drugs for the rest of their life.

However, scientists at the University of California San Francisco hope that can be changed. They have created a bioreactor, a sort of artificial organ that can safely perform the functions of a kidney. It is connected directly to the blood vessels and veins, allowing passage of nutrients and oxygen like the actual kidney would. This bioreactor was tested using a type of kidney cell called a proximal tubule cell, which regulates water. These cells are encased in a silicon membrane with nanopores, which allows the cells to do their job while preventing the body's immune system from identifying and attacking them. These bioreactors were tested in pigs, and after a week the animals experienced no ill effects or rejection.

The next steps will be expanding to month long trials, and including more different kinds of cells in the reactor to perform more of the kidney's functions. Though this technology is still far from being perfected, this is a huge step in the direction of treating kidney disease far more easily and effectively!

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