The Things I Would Do To Get My Hands On This...

The things I would do to get my hands on this...

The silver cigarette case given by Arthur Conan Doyle to Sidney Paget as a wedding gift, inscribed “From Sherlock Holmes” x

John and Sherlock love eachother.

That's it. That"s the post.

If you think differently, with all due respect and on behalf of 137 years of Sherlock Fans, you can shove your opinions up your ass.

Then go find a clue.

This is my favourite Sherlock Holmes story in every adaptation, and I still get giddy everytime the letters back and forth come up, because it's really just Holmes and Watson getting an excuse to send eachother love letters like the sappy old men they are.

Rewatched Granada Hound of the Baskervilles yesterday and Sir Henry knows what’s what.

I just picture Mrs. Hudson gifting these to Sherlock on his birthday <3

Antique Drug Dishes ⋆ ˚｡⋆୨୧˚

THX SO MUCH 4 1K!!! <3

What really gets me going in reading the original Sherlock Holmes stories and seeing the way Watson and Sherlock address eachother and speak of eachother with such casual affection and adoration. Like Doyle wasn’t hiding anything, it isn’t subtext at all.

“My dear Watson.”

“A friend?”

Besides you, my dear Watson, I have none.”

The way Watson speaks of him and his brilliant mind and way of living is like when you’re in love and enchanted for the first time and you don’t even realize it. Like who knew the greatest love story of all time was two raggedy men in a flat in London? Like I’m floored everytime I read it

Cyanide Poison

Let's start by understanding exactly how cyanide kills you. In simple terms, cyanide prevents cells from using oxygen to make energy molecules.

The cyanide ion, CN-, binds to the iron atom in cytochrome C oxidase in the mitochondria of cells. It acts as an irreversible enzyme inhibitor, preventing cytochrome C oxidase from doing its job, which is to transport electrons to oxygen in the electron transport chain of aerobic cellular respiration. Now unable to use oxygen, the mitochondria can't produce the energy carrier adenosine triphosphate (ATP). Tissues that require this form of energy, such as heart, muscle cells, and nerve cells, quickly expend all their energy and start to die. When a large enough number of critical cells die, you expire as well. Death usually results from respiratory or heart failure.

Immediate aymptoms include headaches, nausea and vomiting, dizziness, lack of coordination, and rapid heart rate. Long exposure symptoms include unconsciousness, convulsions, respiratory failure, coma and death.

A person exposed to cyanide may have cherry-red skin from high oxygen levels, or dark blue coloring, from Prussian blue (iron-binding to the cyanide ion). In addition to this, skin and body fluids may give off an almond odor.

The antidotes for cyanide include sodium nitrite, hydroxocobalamin, and sodium thiosulfate.

A high dose of inhaled cyanide is lethal too quickly for any treatment to take effect, but ingested cyanide or lower doses of inhaled cyanide may be countered by administering antidotes that detoxify cyanide or bind to it. For example, hydroxocobalamin, natural vitamin B12, reacts with cyanide to form cyanocobalamin, which leaves the body in urine.

These antidotes are administrated via injection, or IV infusion.

Cyanide is actually a lot more common than you'd think. It's in pesticides, fumigants, plastics, and electroplating, among other things. However, not all cyanide are so poisonous. Sodium cyanide (NaCN), potassium cyanide (KCN), hydrogen cyanide (HCN), and cyanogen chloride (CNCl) are lethal, but thousands of compounds called nitriles contain the cyanide group, yet aren't as toxic. They still aren't terribly good for you, so I wouldn't go around ingesting other cyanide compounds, but they're not quite as dangerous as the lethal kind.

Thank you for reading, have a lovely day :)