I Genuinely Feel This On A Daily Basis, And Having My Biggest Comfort Character (Sherlock Holmes) Say

I genuinely feel this on a daily basis, and having my biggest comfort character (Sherlock Holmes) say that he feels it too was so powerful and wonderful for me.

He makes me feel so seen

(Sherlock quote from The Gloria Scott podcast ep)

This is my favourite Sherlock Holmes story in every adaptation, and I still get giddy everytime the letters back and forth come up, because it's really just Holmes and Watson getting an excuse to send eachother love letters like the sappy old men they are.

Rewatched Granada Hound of the Baskervilles yesterday and Sir Henry knows what’s what.

Agreed

That’s it. “Old Sport” is officially a gay term, and a gay term only.

Cyanide Poison

Let's start by understanding exactly how cyanide kills you. In simple terms, cyanide prevents cells from using oxygen to make energy molecules.

The cyanide ion, CN-, binds to the iron atom in cytochrome C oxidase in the mitochondria of cells. It acts as an irreversible enzyme inhibitor, preventing cytochrome C oxidase from doing its job, which is to transport electrons to oxygen in the electron transport chain of aerobic cellular respiration. Now unable to use oxygen, the mitochondria can't produce the energy carrier adenosine triphosphate (ATP). Tissues that require this form of energy, such as heart, muscle cells, and nerve cells, quickly expend all their energy and start to die. When a large enough number of critical cells die, you expire as well. Death usually results from respiratory or heart failure.

Immediate aymptoms include headaches, nausea and vomiting, dizziness, lack of coordination, and rapid heart rate. Long exposure symptoms include unconsciousness, convulsions, respiratory failure, coma and death.

A person exposed to cyanide may have cherry-red skin from high oxygen levels, or dark blue coloring, from Prussian blue (iron-binding to the cyanide ion). In addition to this, skin and body fluids may give off an almond odor.

The antidotes for cyanide include sodium nitrite, hydroxocobalamin, and sodium thiosulfate.

A high dose of inhaled cyanide is lethal too quickly for any treatment to take effect, but ingested cyanide or lower doses of inhaled cyanide may be countered by administering antidotes that detoxify cyanide or bind to it. For example, hydroxocobalamin, natural vitamin B12, reacts with cyanide to form cyanocobalamin, which leaves the body in urine.

These antidotes are administrated via injection, or IV infusion.

Cyanide is actually a lot more common than you'd think. It's in pesticides, fumigants, plastics, and electroplating, among other things. However, not all cyanide are so poisonous. Sodium cyanide (NaCN), potassium cyanide (KCN), hydrogen cyanide (HCN), and cyanogen chloride (CNCl) are lethal, but thousands of compounds called nitriles contain the cyanide group, yet aren't as toxic. They still aren't terribly good for you, so I wouldn't go around ingesting other cyanide compounds, but they're not quite as dangerous as the lethal kind.

Thank you for reading, have a lovely day :)

Note to self to visit this place the next time I'm in Manchester.

I was wandering around Manchester and came across a little pub/cafe thing called "The Granada"

And I was like "wait.... Is there a chance it's called that because it's on the site where the TV studio was?"

I need to look into it more but yeah, I'm assuming it is and that's the site where the original Coronation Street and Granada Holmes sets were.

The things I would do to get my hands on this...

The silver cigarette case given by Arthur Conan Doyle to Sidney Paget as a wedding gift, inscribed “From Sherlock Holmes” x